Select an upcoming Colon cruise itinerary list below to find a Colon sailing itinerary by destination, line, or ship. Search All Cruises Oceania Cruises11/14/202512 Night Central America & Panama Canal Cruiseon the Oceania Cruises Regatta departing from Colon, PanamaInteriorOceanviewBalconySuite$2,343$2,343$3,093$7,143Ponant02/23/202510 Night South American Cruiseon the Ponant Le Bellot departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability03/15/202512 Night Caribbean Cruiseon the Ponant Le Bellot departing from Colon, PanamaInteriorOceanviewBalconySuite---$18,35012/03/202510 Night South American Cruiseon the Ponant Le Champlain departing from Colon, PanamaInteriorOceanviewBalconySuite--$7,990$12,54012/19/20257 Night South American Cruiseon the Ponant Le Dumont D'Urville departing from Colon, PanamaInteriorOceanviewBalconySuite--$4,760$8,30001/02/20267 Night South American Cruiseon the Ponant Le Dumont D'Urville departing from Colon, PanamaInteriorOceanviewBalconySuite--$4,760$8,30001/16/202612 Night Caribbean Cruiseon the Ponant Le Dumont D'Urville departing from Colon, PanamaInteriorOceanviewBalconySuite--$6,930$11,33001/19/202610 Night South American Cruiseon the Ponant Le Champlain departing from Colon, PanamaInteriorOceanviewBalconySuite--$8,670$15,17002/19/20267 Night South American Cruiseon the Ponant Le Champlain departing from Colon, PanamaInteriorOceanviewBalconySuite--$6,030$10,31003/05/202610 Night South American Cruiseon the Ponant Le Champlain departing from Colon, PanamaInteriorOceanviewBalconySuite--$9,150$14,340Royal Caribbean International10/11/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$709$753$870$1,30910/18/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$756$759$850$1,30910/25/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$680$730$840$1,35911/01/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$809$859$960$1,35911/08/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$679$709$880$1,35911/15/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$658$713$900$1,92911/22/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$666$747$920$1,50911/29/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$659$740$909$1,50912/06/20256 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$674$755$924$1,52412/12/20258 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$796$839$995$1,50412/20/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$830$909$1,109$1,80912/27/20257 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$1,009$1,059$1,259$1,95901/03/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$659$739$959$1,65901/10/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$726$804$984$1,56801/17/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$759$766$859$1,52901/24/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$639$669$839$1,52901/31/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$659$689$839$1,49802/07/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$609$659$859$1,50802/14/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$659$689$880$1,54902/21/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$559$639$859$1,54902/28/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$659$739$972$1,65903/07/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$642$742$972$1,65903/14/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$642$742$972$1,65903/21/20267 Night Southern Caribbean Cruiseon the Royal Caribbean International Serenade of the Seas departing from Colon, PanamaInteriorOceanviewBalconySuite$642$742$972$1,659Windstar Cruises03/01/202511 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Wind Star departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability03/15/202511 Night Caribbean Cruise Colombian & Southern Caribbean Coastlineson the Windstar Cruises Wind Star departing from Colon, PanamaInteriorOceanviewBalconySuite-$3,198--11/29/20257 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Wind Spirit departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability11/29/20257 Night Central America & Panama Canal Cruise Costa Rica & Panama Canalon the Windstar Cruises Wind Spirit departing from Colon, PanamaInteriorOceanviewBalconySuite-$4,199--11/29/20257 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Wind Spirit departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability12/13/20257 Night Central America & Panama Canal Cruise Enchanting Colombia and Panamanian Islandson the Windstar Cruises Wind Spirit departing from Colon, PanamaInteriorOceanviewBalconySuite-$2,999--12/13/20257 Night Central America & Panama Canal Cruise Costa Rica & Panama Canalon the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuite-$2,599$3,859$5,09912/27/202511 Night Central America & Panama Canal Cruise Marvels of Ecuador, Peru, and the Panama Canalon the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuite-$4,999$6,469$7,69912/27/202515 Night Central America & Panama Canal Cruise Marvels of Latin America Cruise Touron the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability01/18/202611 Night Central America & Panama Canal Cruise Marvels of Ecuador, Peru, and the Panama Canalon the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuite-$4,799$6,369$9,79901/18/202615 Night Central America & Panama Canal Cruise Marvels of Latin America Cruise Touron the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability02/09/20267 Night Central America & Panama Canal Cruise Costa Rica & Panama Canalon the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuite-$3,199$4,459$5,69902/09/20267 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability02/09/20267 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability02/09/20268 Night Central America & Panama Canal Cruise Mayan Legacieson the Windstar Cruises Wind Surf departing from Colon, PanamaInteriorOceanviewBalconySuite-$3,299-$4,19902/09/202619 Night Central America & Panama Canal Cruise Star Collector: Caribbean Cultures: Latin America & the Greater Antilleson the Windstar Cruises Wind Surf departing from Colon, PanamaInteriorOceanviewBalconySuite-$6,099-$7,89902/23/20267 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability02/23/20267 Night Central America & Panama Canal Cruise Costa Rica & Panama Canalon the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuite-$2,999$4,259$6,39902/23/20267 Night Central America & Panama Canal Cruise Monteverde Cloud Forest & Arenal Volcano Cruise Touron the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuiteContact cruise line for pricing & availability03/09/20266 Night Central America & Panama Canal Cruise Panama’S Pristine Caribbeanon the Windstar Cruises Star Pride departing from Colon, PanamaInteriorOceanviewBalconySuite-$2,399$3,659$4,899